In this research we aim to demonstrate a flexible, low-cost, highly sensitive graphene-based field-effect transistor (FET) biosensor to detect the cancer biomarker prostate specific antigen (PSA). Flexible biosensors are promising for skin wearable and implant applications. We combine the large-area ink-jet printing technology and wet-transfer of graphene to dramatically reduce the cost of biosensor, making disposable biosensors affordable.
Monolayer graphene is a two-dimensional carbon material with all of its atoms exposed to external environment. The electronic properties of graphene are sensitive to a tiny change of chemical environment. Furthermore, graphene has remarkably high electron mobility at room temperature. It is also flexible, strong, light weight, and transparent. All these properties are ideal for flexible biosensor applications. In order to improve the selectivity of the biosensors, the graphene will be chemically functionalized with bioreceptors that target the speciﬁc biomarker being detected.
The long-term goal is to fabricate multiplexed biosensors based on graphene FET-array for simultaneous detection of multiple bio-agents.